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CYCLIN-DEPENDENT KINASE INHIBITOR P16
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor p16
Descriptor
Spanish
:
Inhibidor p16 de la Quinasa Dependiente de Ciclina
Descriptor
Portuguese
:
Inibidor p16 de Quinase Ciclina-Dependente
Tree Number:
D12.644.360.225.200
D12.776.167.187.200
D12.776.476.225.200
D12.776.624.776.355.200
Definition
English
:
A product of the p16 tumor suppressor gene (
GENES
, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is
TUMOR SUPPRESSOR PROTEIN P14ARF
. Both p16 gene products have tumor suppressor functions.
See Related
English
:
Genes, p16
Tumor Suppressor Protein p14ARF
History Note
English
:
2006(1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33490
Unique Identifier:
D019941
Occurrence in VHL
:
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